Evidence indicated that the Alzheimer's disease (AD) pathway is also related to CAD because some factors that induced AD could also be CAD risk factors, e.g. the variants of apolipoprotein E (especially Allele epsilon4), apolipoprotein B, altered cholesterol levels, particularly high levels of low-density lipoproteins together with low levels of high-density lipoproteins [55], [56], [57], [58]. Here, APOB is linked to early-onset autosomal dominant Alzheimer disease.