McCarthy et al. validated that CAD is associated with gene pairs LRP1 (GeneID: 4035) and MTHFR (GeneID: 4524) in interacting disease-risk modules 4945 and 638, and LRP1 and SELP (Gene ID: 6403) in interacting modules 4945 and 4393 [63]. The gene discussed is MTHFR; the disease is coronary artery disorder.