NPY and status epilepticus: This is supported by many previous observations, which comprise an increased hippocampal NPY expression in response to status epilepticus in young adult rats as a compensatory means to reduce seizures [32], [44], [45], seizure activity in response to reduced levels of NPY [45], and a reduced epileptiform-like activity with the administration of NPY in animal models of epilepsy [46]–[49].