It is also expressed in certain normal tissues where it functions in the regulation of cell proliferation, cell migration, transmission of survival signals, and other cell-cell and cell-matrix interactions [9], [10], [11], [12], [13] demonstrated that CD44 antagonists attenuate in vivo growth of mouse tumors derived from glioma cell lines, suggesting that CD44 is a potential therapeutic target for GBM. Here, CD44 is linked to central nervous system cancer.