MYBPC3 and heart failure: Myosin-binding protein C (MyBP-C) is a key constituent of cardiac muscle thick filaments, which by interacting with myosin,[8], [9], [10] titin[11] and actin[12] contributes to the structural integrity of the sarcomere and regulates cardiac contractility in response to adrenergic stimulation.[13], [14] Mutations in MYBPC3 result in disorganized sarcomeric structure, thus MYBPC3 has emerged as an important gene for increased risk of heart failure through cardiomyopathies (DCM and HCM).[15], [16], [17], [18]