FBXW7 and acute lymphoblastic leukemia: Others have shown that combining ABT-737 with agents decreasing Mcl-1 protein expression act synergistically with ABT-737 [15], [16], and depletion of Mcl-1 restores ABT-737 sensitivity in Fbw7-deficient T-Cell Acute Lymphoblastic Leukemia cells, indicating that elevated Mcl-1 expression is important for Fbw7-deficient cells to evade apoptosis [17].