Second, although there was strong association between CRP haplotypes with CRP concentrations, the CRP genotype did not associate strongly (all P≥0.039) or consistently in the hypothesized direction with cognitive decline, in stark contrast to the observed more robust (all P≤0.007) and directionally consistent effects of apolipoprotein E (APOE) polymorphisms on cognition. The gene discussed is APOE; the disease is Mental deterioration.