Moreover, in adult counterpart, considering that ZOL or PAM exert also anti-cancer activity by inducing apoptosis, ABs, as other anticancer agents, may interfere in the complex interaction between tumor and host immune system by the release of inflammatory mediators, such as HMGB1, which mediate cross-presentation of tumor antigens via binding on TLR4 and the promotion of tumor specific cytotoxic T cell responses [55], [56]. This evidence concerns the gene HMGB1 and neoplasm.