SHBG and neoplasm: Moreover, they may exert effects via oestrogen receptor-independent mechanisms, such as inhibition of tumour growth and angiogenesis, as well as stimulation of apoptosis and of sex hormone-binding globulin production (SHBG) (Adlercreutz et al, 1987; Power et al, 2006; Adlercreutz, 2007; Mense et al, 2008; Saarinen et al, 2008, 2010).