Germline mutations in CDKN2A and CDK4 (Udayakumar and Tsao, 2009) have been linked to familial melanoma, however mutations in both of these genes have been infrequently reported in young onset melanoma (Tsao et al, 2000; Berg et al, 2004; Debniak et al, 2008). The gene discussed is CDK4; the disease is melanoma.