Brain metastases have been found to be associated with HR-negative and triple-negative (ER-, PgR-, HER2-) breast cancers [8,12,14,15,24,30], EGFR expression [15], low Bcl-2 [15], and breast cancer HER2 expression and presence of HER2 amplification [12,16,31]. Here, ESR1 is linked to breast carcinoma.