LOX and cancer: Since the spatial organisation of collagen and elastin fibers can determine the mode of invasion, i.e. whether the cells move amoeboid-like, protease-independent, or mesenchymal, it may be appealing to first alter the stiffness of the ECM by treatment with LOX-inhibitors (see above) in order to force cancer cells to adopt a particular mode of invasion and subsequently apply inhibitors that specifically target this invasion mode.