On the one hand cancer cells respond to this environment through modulation of cell adhesion/migration molecules (e.g. L1-CAM, integrins), contact guidance, cytoskeletal reorganisation, cell shape changes, as well as secretion of proteolytic enzymes (MMP-7/-9), growth factors (HB-EGF), chemokines, and cytokines (TNFα, TGF-βs). This evidence concerns the gene HBEGF and cancer.