TIMP1 and Hepatic fibrosis: Serum levels of procollagen peptide (types III and IV), the P1 fragment of laminin, hyaluronic acid, fibrosin, TNF-aR-II and sICAM-1, tissue inhibitors of matrix metalloproteinases (TIMP)-1, and platelet-derived growth factors (PDFG)-BB may be elevated in patients with severe hepatic fibrosis [5], [42].