Since altered expression of miR-224 and miR-383 was observed in tumors of tissues expressing type 1 iodothyronine deiodinase it suggests that these tumors may also present disturbed expression of DIO1. Indeed, in papillary thyroid cancers, expression of miR-224 was significantly elevated (39) while our studies revealed that in this cancer, expression of DIO1 is reduced (3). Here, DIO1 is linked to cancer.