The gene encoding endothelial nitric oxide synthase (protein: eNOS; gene: eNOS) is regarded as one of the potentially logical candidate for hypertension, since its enhanced production or enzyme bioavailability can lead to the constitutive release of nitric oxide in endothelial cells, which exerts vasoprotective effects in blood pressure (BP) regulation [3]. This evidence concerns the gene NOS3 and hypertensive disorder.