Our results provided strong evidence for the involvement of PLC, Class II PI3K/AKT/Rho-A, IκBα/NFκB and ERK, but not of Class I PI3K or P38 MAPK, in CXCL-12/CXCR4-mediated MM cell chemotaxis. Here, CXCR4 is linked to Miyoshi myopathy.