Since CXCL12-mediated chemotaxis of MM cells involves PLC, PI3K, RhoA, NF-κB and ERK1/2, we specifically investigated the phosphorylation status of PLCβ3, AKT, IκBα and ERK1/2 and the activation status of RhoA (an important protein for the adhesion of MM cells) following the stimulation of MDN cells with CXCL12 (Figure 2). Here, AKT1 is linked to Miyoshi myopathy.