Patients with HCC (n = 141) were divided into 2 groups according to the median of circulating PD-1/PD-L1 expression: those with low PD-1/PD-L1 expression (<10.88%/9.18) and those with high PD-1/PD-L1 expression (≥10.88%/9.18). This evidence concerns the gene PDCD1 and hepatocellular carcinoma.