After cryoablation therapy, tumor cells were degenerated, disaggregated and up-taken by antigen presenting cells, e.g. kuffer cells, pDC and mDC, which lead to the secretion of a large mount of proinflammatory cytokines, including IFN-α,IFN-γ and gamma-chain cytokines. This evidence concerns the gene IFNG and neoplasm.