A GWAS of BMI and weight in almost 32,000 individuals of primarily European descendant validated the associations with FTO and MC4R. Moreover, genome-wide significant associations for variants in/near two genes formerly suggested as biological candidate genes for obesity, BDNF and SH2B1 were observed, together with the identification of seven new BMI/weight loci, TMEM18, KCTD15, NEGR1, SEC16B, ETV5, FAIM2 and BAT2[19]. The gene discussed is MC4R; the disease is obesity due to melanocortin 4 receptor deficiency.