SEC16B and obesity due to melanocortin 4 receptor deficiency: Our analyses show the same trends towards increased obesity risk, for all variants except rs10508503 near PTER. We report significant associations with overweight and/or obesity for the risk variants in/near BDNF, TMEM18, ETV5 and GNPDA2. In extended follow-up analyses of anthropometric and metabolic traits in the population-based Inter99 cohort we identified associations with risk alleles in/near BDNF, TMEM18, GNPDA2, SEC16B and FAIM2 when no adjustments for BMI were made.