A different pattern was observed for the TMEM18 rs7561317 G-allele, which strongly associated with obesity with an OR of 1.25 (1.14–1.37, p = 2.1×10−6) and with morbid obesity with an OR of 1.46 (1.17–1.82, p = 8.3×10−4) per allele, but not with overweight. This evidence concerns the gene TMEM18 and obesity due to melanocortin 4 receptor deficiency.