SH2B1 and obesity due to melanocortin 4 receptor deficiency: In conclusion, of the variants found to associate with obesity and related traits in the second GWAS wave, we were able to report association with obesity and/or measures of adiposity for variants in/near BDNF, TMEM18, ETV5, GNPDA2, SEC16B and FAIM2. Moreover, we found that SH2B1 rs7498665 strongly associated with type 2 diabetes in a BMI-independent manner.