Considering the literature suggesting that dopamine-related genes such as some polymorphisms of the dopamine transporter gene are uniquely expressed in BD [31], altered dopamine tone may be an important neurobiological feature of the illness of BD and not unique to manic episodes Furthermore, our findings suggest that acute administration of medications in animals may not be the most appropriate way to validate animal models of mania. Here, SLC6A3 is linked to manic or hypomanic episode.