Our investigation revealed that six of these genes (PDE4B, SPRR2B, ADCY2, KIF3A, DNAH5, and PLAU; see Table 1) were located in chromosomal regions that had been previously linked to asthma or other allergic disease phenotypes and had been shown to be regulated during allergic inflammation [1] (Table 1). Here, PLAU is linked to asthma.