TNF and Friedreich ataxia: Second, it has been suggested that hematopoietic disorders in FA patients may result from hypersensitivity to cytokines, such as TNF-α; for example, cells lacking FANCC, a core complex component, are hypersensitive to the apoptotic effect of a pro-inflammation cytokine, TNF-α[9], [10], [11], [12], [13], [14].