Later, after infection, vacuoles containing replicating ehrlichiae show the characteristics of early endosomes (i.e., the presence of Rab5A, early endosomal antigen 1 (EEA1), and vacuolar (H+) ATPase, together with vesicle-associated membrane protein 2, major histocompatibility class II and β2-microglobulin) and accumulate transferrin and its receptor. The gene discussed is EEA1; the disease is infection.