In addition, compared to subjects expressing physiologic levels of G6PD, the prognosis in G6PD- deficient patients is relatively poor, due to complications, such as hemolysis (involving red blood cells which lack the ability to synthesize G6PD to replace unstable prematurely denatured G6PD) and acute renal failure (as consequence of hemolysis), and enhanced severity of disease. This evidence concerns the gene G6PD and acute kidney injury.