Thus, unrestrained GAT-1 KO mice (GAT-1−/−), which have not undergone any pharmacological treatment and whose TC neurons display enhanced tonic GABAA currents in vitro express ethosuximide-sensitive typical absence seizures (Figures 4(a), 4(b) and 4(c)) [36]. Here, SLC6A1 is linked to Generalized non-motor (absence) seizure.