SLC6A1 and juvenile absence epilepsy: In summary; therefore, genetic models of typical absence seizures (i.e., GAERS, stargazer, and lethargic mice) show a brain region-specific enhancement of tonic GABAA current, which in TC neurons is due to increased extracellular GABA level that in turn results from a malfunction in GABA uptake by astrocytic GAT-1.