BRAF and melanoma: A high frequency of aberrations in the BRAF gene is observed in Non-CSD (CSD:chronic sun-induced damage) melanomas [8, 12], while the BRAF V599E mutation has a relatively low frequency in other subtypes of melanomas, including frequencies ranging from 15% to 33% in acral melanomas, which occur on the palms, soles and subungual sites [8, 10], but almost 0% in mucosal melanomas [9, 10].