NUAK2 and colorectal carcinoma: Another study with a carcinogen (azoxymethane) induced colorectal tumorigenesis model using NUAK2-deficient mice has shown that hemiallelic loss of NUAK2 contributes to carcinogen-induced neoplastic and preneoplastic lesions of colorectal carcinomas, which suggests there are tumor suppressive roles of NUAK2 in the early phase of tumorigenesis and suggests the minor effects of NUAK2 deficiency on cell proliferation in vivo from the profile of the proliferating cell population [83].