NUAK2 and melanoma: Univariate analysis using Kaplan-Meier curves showed that high expression of NUAK2 has an impact on relapse-free survival of acral melanoma patients (P = 0.0036), and multivariate analysis using multiple Cox regression analysis also showed the impact of NUAK2 on relapse-free survival (hazard ratio = 3.88, 95% confidence interval = 1.44-10.50, P = 0.0075).