TXNIP and Hyperglycemia: As expected, phloretin blocked the hyperglycemia effect on TXNIP RNA level (1.5 ± 0.05 vs. 1.03 ± 0.03, p < 0.01) (Figure 4A) and significantly reduced ROS (2.1 ± 0.08 vs 1.84 ± 0.14, p < 0.05) in ARH77 cells (Figure 4B).