Based on both observations that DEX induces hyperglycemia and that hyperglycemia may interfere with the cell response to drugs, we investigated the axis TXNIP-ROS-TRX in conditions of increased level of glucose (e.g., mimicking in vivo conditions of hyperglycemia) and in response to DEX in a pool of cells derived from multiple myeloma. This evidence concerns the gene TXNIP and AL amyloidosis.