XRCC6 and ischemia: This function of Ku70, whose levels increase after an ischemic insult, has been linked to a decrease in apoptosis after neonatal rat ischemia [127], and a Bax-inhibiting peptide, based on the Bax-Ku70 inhibiting domain, has proved to inhibit apoptosis and improve neurological outcome in rats subjected to global cerebral ischemia [128].