PGC-1α has been shown to be induced after transient global ischemia, where it protects hippocampal neurons from delayed cell death, and knocking down the gene results in lower expression of UCP2 and the antioxidant enzyme superoxide dismutase 2 (SOD2) leading to neuronal death from oxidative stress [130]. The gene discussed is PPARGC1A; the disease is ischemia.