Studies using in vivo and in vitro stroke models have identified several proteins and signalling pathways that can protect neurons against ischemic injury, including: neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF); protein chaperones, including heat shock protein 70 (Hsp70) and glucose regulated protein 78 (GRP78); antioxidant enzymes, such as heme oxygenase-1 (HO-1) and the regulator of mitochondrial biogenesis PGC-1α. This evidence concerns the gene PPARGC1A and stroke disorder.