Levels of inflammatory markers, such as C-reactive protein, tumor necrosis factor (TNF) and interleukin 6 (IL-6), increase with age and obesity, and decrease accordingly with CR [81], and the mediators of this decline are various, including the already mentioned Hsp70, PGC-1α and neurotrophic factors such as BDNF, but here we will focus on two key proteins involved which are SIRT1 and mTOR. The gene discussed is TNF; the disease is obesity disorder.