PTGS2 and ischemia: In adult ratsand mice, pretreatment with troglitazone, rosiglitazone, or pioglitazone (i.p.)prior to ischemia was shown to decreasethe infarct volume, microglial activation, macrophage infiltration, and expressionof proinflammatory genes cyclooxygenase-2 (COX2),iNOS, and IL-1β mRNA in the ischemic hemisphere [32, 66, 68].