Intriguingly, as for PLCD1, low expression of PLCE1 was strongly associated with mutations in KRAS. Since PLCE1 is found to be both an upstream and downstream effector of Ras family proteins [30], the correlation of mutated KRAS with the reduced expression levels most likely plays a critical role in CRC tumorigenesis. The gene discussed is PLCE1; the disease is colorectal carcinoma.