We selected the “Phosphatidylinositol signaling network” and two of the deregulated components therein, PLCD1 (HGNC:9060) and PLCE1 (HGNC:17175), for detailed studies and compared the findings with clinicopathological data and mutation status of several genes known to be altered in CRC. This evidence concerns the gene PLCD1 and colorectal carcinoma.