PLCE1 and rectal cancer: The observed repression of PLCE1, the second gene investigated in detail, is supported by the results from Sorli et al. who also demonstrated significantly reduced mRNA expression levels in colon and rectum cancer samples and colon cancer cell lines, as well as by Wang and colleagues who reported a frequency of 36% loss of heterozygosity (LOH) of 10q23 where PLCE1 is located and downregulation of PLCE1 in 21/50 colorectal cancer samples compared with matched normal tissue [27]–[29].