IFNB1 and infection: To confirm that C6 impaired IFN-β and IFN-β-dependent gene expression in innate immune cells, we infected human moDCs with increasing doses (0.002, 0.02 and 0.2 PFU/cell) of MVA, MVA-B and MVA-B ΔC6L and measured IFN-β, IFIT1 and IFIT2 mRNA levels 6 h post-infection (Figure 3B).