This raises the question as to whether VWF co-storage of FVIII variants displaying a reduced ability to associate with VWF represents a general phenomenon in mild/moderate hemophilia A. We have therefore extended our initial observation regarding the Tyr1680Phe variant to a larger panel of mild/moderate hemophilia A causing FVIII variants, including amino acid replacements in the FVIII C1 and C2 domains. Here, F8 is linked to hemophilia A.