High Spry2 gene expression was consistently associated with better prognosis (optimal cutpoint HR 1.49, 96% CIs 1.21–1.84, p<0.0001), particularly in those tumours expressing very high levels of Spry2 (HR 2.71, 95% CIs 1.34–5.46, p = 0.005), consistent with the accepted role of Sprouty 2 as a tumour suppressor gene (Figure 3). Here, SPRY2 is linked to neoplasm.