PSMB8 and myocarditis: Consequently, we observed significantly enhanced ALIS formation in the injured myocardium (evaluation of poly-ub-aggregates at the acute stage of myocarditis: β5i/LMP7+/+ mice: 13.5 ALIS / 1088 μm2±1.0 vs. β5i/LMP7-/- mice: 20.0 ALIS / 1088 μm2±1.8; p<0.05; n = 5 mice).