Likewise, CVB3 titers were within the same range in IP-deficient and wildtype control mice in acute myocarditis (Fig. 4) and the virus was efficiently eliminated in both hosts at d28 p.i. These findings support the induction of efficient CD8 T cell responses also in CVB3-challenged IP-deficient mice, which is in agreement with observations in other infection models: the kinetics of lymphocytic choriomeningitis virus clearance were similar in both β5i/LMP7+/+ and β5i/LMP7-/- mice [34]. Here, CD8A is linked to myocarditis.