We have shown that HIV-1 infected T cells polarize their MTOC and associated organelles at sites of cell-cell contact that aligns the secretory apparatus proximal to the VS; that HIV-1 Env colocalizes with SL-related organelles in CD4+ T cells; and that CD4+ T cells disabled for regulated secretion are less able to support spreading HIV-1 infection. The gene discussed is CD4; the disease is HIV-1 infection.