We were particularly interested in the PH domain, as recent studies have shown that multiple proteins that regulate PI4P metabolism are recruited to the inclusion, including OCLR (oculocerebrorenal syndrome of Lowe protein 1) and the PI4P kinases, PI4KIIα and to a lesser extent PI4KIIβ [40]. The gene discussed is PI4K2B; the disease is oculocerebrorenal syndrome.