LCN2 and acute kidney injury: Unfortunately, all actually studied biomarkers have insufficient sensitivity to detect AKI in the ICU, and diagnostic power may only increase when a combination of various biomarkers is used, including cystatin-C, Neutrophil gelatinase-associated lipocalin (NGAL) in the serum and urine, IL-18, and kidney injury molecule 1 (KIM -1) [34-36].