In testing the hypothesis that aberrant glycoforms of PSA may help detect aggressive prostate cancers, we studied 13 individual glycan profiles of PSA enriched from prostate tissue specimens: 2 normal (N), 3 normal tissues from prostates with non-aggressive tumors (NAN), 3 cancerous tissues from the same prostates as NAN (NAT), 3 normal tissues from prostates with aggressive tumors (AN), and 2 cancerous tissues from the same prostates as AN (AT). Here, KLK3 is linked to Familial prostate cancer.