For instance, MyHC-2A (AB025260), PPAP2C (FJ436381) and APOH (AK232456) had tissue-specific alternative splicing in LD, AF and liver, respectively, corresponding to their roles in normal muscle development and function [31], converting phosphatidic acid to diacylglycerol [32], transportation of fatty acids [29], and lipoprotein metabolism [33] (Additional file 11). Here, APOH is linked to atrial fibrillation.