First, various anti-cancer agents specifically up-regulate the expression of p27 without directly affecting expression of other G1-to-S phase cell cycle regulatory proteins including INK4s, p57(Kip2), p21(Cip1Waf1), D-type cyclins, cyclin E, cyclin A, CDK2, CDK4 and CDK6 [1-3]. Here, CDKN1B is linked to cancer.