Women with elevated serum leptin level and sFlt-1/PlGF ratio had substantially higher odds for having preeclampsia than those with elevated sFlt-1/PlGF ratio or serum leptin concentration alone (OR (95% CI): 80.5 (14.4-450), p < 0.001 versus 9.0 (2.80-29.0), p < 0.001 and 9.33 (2.27-38.4), p < 0.05, respectively), even after adjustment for BMI at blood collection in multiple logistic regression analyses (adjusted OR (95% CI): 65.9 (9.47-459), p < 0.001 versus 6.91 (1.55-30.7), p < 0.05 and 1.42 (0.15-13.0), p > 0.05, respectively). This evidence concerns the gene LEP and preeclampsia.