This invasive ability was investigated in a study by Yamashita et al. (2006) [13] using the invasive cancer cell line SKOV-3, which overexpresses HOXB7 and HOXB13. Antisense HOXB7 and HOXB13 fragments were introduced into SKOV-3 cells which results in an 85% and 50% reduction of motility, respectively, suggesting a role in cancer cell invasion. The gene discussed is HOXB13; the disease is cancer.