HOXB7 is one of the HOX genes which shows a markedly higher expression in ovarian cancer cell lines compared to normal ovarian epithelia [15] and promotes growth in ovarian epithelial cells [11], but it also plays a novel role in DNA double-strand break repair through interacting with proteins that act as genomic caretakers, including members of the DNA-dependent protein kinase haloenzyme, Ku70, Ku80 and DNA-PKcs [25]. The gene discussed is HOXB7; the disease is ovarian carcinoma.