HOXA11 and cancer: Fiegl et al. (2008) [39] analysed the DNA methylation of 71 genes in 22 ovarian cancers and 18 non-neoplastic samples and identified the best discriminators between cancer and non-neoplastic tissue as being HOXA10 and HOXA11. In particular HOXA11 methylation was strongly associated with poor outcome, suggesting a possible role for DNA methylation as a prognostic marker in ovarian cancer.