Further more and in accordance with previous reports [55], we found decreased expression of PH-associated genes BMPR2 and of BMPR1A in both, MCT and MCT/PE, underlining the molecular similarities of those two animal-models with human familial or idiopathic PAH when it comes to alterations of BMP/TGF-β signaling. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.