At this moment, we are not able to state whether the increased VEGF-A and CCL2 mRNA is a consequence of genetic and/or epigenetic changes of upstream regulatory sequences, altered transcriptional regulation or amyotrophy and thus the present report lays the foundation for future studies to screen promoter elements of VEGF-A and CCL2 in Indian ALS population for subtle genetic differences. Here, CCL2 is linked to amyotrophic lateral sclerosis.