The elevated PBMCs VEGF-A is in contrast to previous reports where a profound downregulation of VEGF-A mRNA in SOD1G93A ALS mouse and significantly reduced serum and cerebrospinal fluid (CSF) VEGF-A in ALS patients was observed possibly because of genetic changes in promoter regions [15-17]. Here, VEGFA is linked to amyotrophic lateral sclerosis.