Interestingly, KCC2 and NKCC1 transcript levels were not altered in subjects with schizophrenia; however, transcripts for two kinases (OXSR1 and WNK3) that strongly regulate KCC2 and NKCC1 activity in opposite directions, are overexpressed in schizophrenia [232]. Here, SLC12A2 is linked to schizophrenia.