INF2 and focal segmental glomerulosclerosis: Interestingly, all of the 13 INF2 mutations associated to FSGS lie within the DID region of the protein [127, 128], and six of them are localized in the corresponding INF2 region of a mDia1 DID subdomain interacting with IQ motif-containing GTPase-activating protein (IQGAP1) [128].