In particular, two isoforms of nPKCs, PKCδ, and PKCε show opposite effects on apoptosis: activation of PKCδ induces and/or enhances the apoptotic events that occur during ischemia-reperfusion and malignant progression of cancer cells, whereas activation of PKCε inhibits and/or reduces these events (recently reviewed in [244]). This evidence concerns the gene PRKCE and cancer.