AKT1 and acute myeloid leukemia: Overexpression of these pathways in acute myeloid leukemias (AML) has been associated with a worse prognosis than overexpression of a single pathway [9], while activation of the MAPK (Raf/MEK/ERK) cascade is suppressed in some prostate cancer cell lines which express high levels of activated Akt [10, 11].