However, recent studies make it likely that p75NTR plays different roles in Alzheimer's disease [1–3], Parkinson's disease [4], differentiation and synaptic connectivity along the neuraxis [23], resistance of neural tumors to chemotherapy [6], and migration of glioblastoma cells away from the primary tumor [5]. The gene discussed is NGFR; the disease is early-onset autosomal dominant Alzheimer disease.