In addition, 23 genetic human prion diseases were diagnosed based on the genetic assays of PRNP, including ten FFI (D178N/M129M) cases, two GSS (P102L) cases, five T188K gCJD cases, two G114V gCJD cases, one E196K gCJD case, one E200K gCJD case, one R208H gCJD case and one gCJD cases with one extra-octarepeat insertion. Here, PRNP is linked to prion disease.