Therefore, we further analysed the possible association between the polymorphisms in HLA-DP gene and the disease progression of chronic hepatitis B. Unfortunately, compared with asymptomatic HBV carrier, there were no associations in chronic active hepatitis B group, HBV-related liver cirrhosis group and HBV-related hepatocellular carcinoma group. This evidence concerns the gene HLA-DPA1 and hepatocellular carcinoma.