However, rosiglitazone, and other PPARγ agonists of the thiazolidinediones (TZD) class of anti-diabetic drugs, are unlikely to be adopted by gastroenterologists for the treatment of IBD due to associated side effects [17] including hepatotoxicity, weight gain, fluid retention leading to edema, and congestive heart failure [18]. The gene discussed is PPARG; the disease is inflammatory bowel disease.