Li et al. [12] demonstrated that multiple ER stress markers, including 78 kDa glucose-regulated protein (GRP78), phosphoinositol-requiring transmembrane kinase (IRE)1α, and phosphor-eIF2α were significantly upregulated in the retinas of animal models of type 1 diabetes and oxygen-induced retinopathy. Here, HSPA5 is linked to type 1 diabetes mellitus.