Loss-of-heterozygosity studies and DNA mutational analysis of cyst fluid have shown that the presence of a point mutation in the KRAS gene is 96% specific in detecting a mucinous neoplasm, and when there is a KRAS gene point mutation coupled with allelic loss at selected markers, there is a 96% specificity in detecting malignancy (invasive versus in situ carcinoma not specified) [41]. This evidence concerns the gene KRAS and cyst.